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GHS Category - Reproductive Toxicity
Posted Date:2022/7/1 1
GHS Definition:
Reproductive toxicity includes adverse effects on adult male and female sexual function and fertility, as well as developmental toxicity in offspring. The definitions below are adapted from the working definitions agreed in IPCS/ESH document No. 225, Principles for Assessing Reproductive Health Risks Arising from Exposure to Chemicals. For classification, genetically heritable effects known to be induced in offspring have been discussed in Germ cell mutagenicity (chapter 3.5), since in the current Germ cell mutagenicity hazard categories are discussed.
In this classification system, reproductive toxicity is further grouped under two main headings:
(a) adverse effects on sexual function and fertility;
(b) Adverse effects on offspring development.
Reproductive toxicity criteria:
|
Category
|
Standard
|
|
Category 1
|
Known or putative human reproductive toxicant
|
|
Category 1A
|
Known Human Reproductive Toxicants
|
|
Category 1B
|
Putative human reproductive toxicant
|
|
Category 2
|
Suspected Human Reproductive Toxicant
|
|
Affects breastfeeding or has effects through breastfeeding
|
Examples of reproductive toxic chemicals:
▪Acrylamide
▪Lithium hypochlorite
▪Tributyltin acetate
▪Manganese
▪Lead iodate
▪3-Butenenitrile
▪p-nonylphenol
Labeling and classification of reproductive toxicity:
|
Classification
|
Label
|
Hazard statement
|
|
Hazard category
|
Hazard classification
|
Pictograms
|
Signal word
|
Hazard statement
|
|
GHS
|
United Nations Model Regulations
|
|
Reproductive toxicity
|
1
(Subclasses 1A and 1B)
|
|
None
|
Danger
|
May cause damage to fertility or to the fetus
|
H360
|
|
2
|
|
None
|
Warn
|
Suspected of causing damage to fertility or to the fetus
|
H361
|
|
Additional classification for effects on or through breastfeeding
|
None
|
None
|
None
|
May cause harm to breastfed children
|
H362
|