Archive Year
For a sample document,quotation,or more information pleasecontact us.
Offering the fastest turn-around times in the industry. Learn more aboutour services.
Gain industry tips and requirements from our team of experts.How We Work.
You are here：Home > news2022
GHS Category - Serious Eye Damage Eye Irritation
Posted Date:2022/7/22
GHS Definition:
Serious ocular damage is ocular tissue damage, or severe physiological visual impairment, which is not fully reversible within 21 days of application, following application of a test substance to the anterior surface of the eyeball. Eye irritation was an ocular change following application of the test substance to the anterior surface of the eye, but was fully reversible within 21 days of application.
Serious eye damage Eye irritation criteria:
|
Category
|
Standard
|
|
Category 1
|
Category 1
substance:
(a) has an effect on the cornea, iris or conjunctiva of at least one animal, and the effect is usually
not reversible or fully reversible during the 21-day observation period; and/or
(b) Calculated from grading at 24 hours, 48 hours and 72 hours after the instillation of the test substance
The mean of , at least two of the three test animals showed positive reactions:
(i) Corneal opacity ≥ 3; and/or
(ii) iritis > 1.5.
|
|
Category 2/2A
|
Average calculated from grading at 24 hours, 48 hours and 72 hours after the instillation of the test substance
Score, at least two of the three test animals showed positive reactions:
(a) Corneal opacity ≥ 1; and/or
(b) iritis ≥ 1; and/or
(c) Conjunctival hyperemia ≥ 2; and/or
(d) Conjunctival edema (conjunctival edema) ≥ 2
But it was fully reversible within the usual 21-day observation period.
|
|
Category 2B
|
In subcategory 2A, eye irritation if the effects listed above are fully reversible within a 7-day observation period
is considered a minor eye irritant (category 2B).
|
Serious eye damage Examples of eye irritation:
▪Phenol
▪Phenolic disulfonic acid sulfuric acid solution
▪Phenolsulfonic acid
▪Sodium phenolate
▪Benzenesulfonyl chloride
▪ N-phenyl-2-naphthylamine
▪2-Phenylphenol
Labeling and classification of eye irritation for serious eye damage:
|
Classification
|
Label
|
Hazard statement code
|
|
Hazard category
|
Hazard classification
|
Pictograms
|
Signal word
|
Hazard statement
|
|
GHS
|
United Nations Model Regulations
|
|
Serious eye damage Eye irritation
|
1
|
|
None
|
Danger
|
Cause serious eye damage
|
H318
|
|
2/2A
|
|
None
|
Warn
|
Causes serious eye irritation
|
H319
|
|
2B
|
None
|
None
|
Warn
|
Cause eye irritation
|
H320
|