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GHS Category - germ cell mutagenicity
Posted Date:2022/6/29
GHS Definition:
This hazard category is primarily for chemicals that have the potential to cause mutations in human germ cells that can be passed on to offspring. However, when classifying substances and mixtures within this hazard class, in vitro mutagenicity/reproductive toxicity tests and in vivo somatic cell mutagenicity/reproductive toxicity tests in mammals are also considered.
Germ cell mutagenicity criteria:
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Category
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Standard
|
|
Category 1
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Substances known to cause heritable mutations in human germ cells or thought to be likely to cause heritable mutations in human germ cells
|
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Category 1A
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Substances known to cause heritable mutations in human germ cells
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Category 1B
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Substances that should be considered likely to cause heritable
|
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Category 2
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Substances of concern due to their potential to cause heritable mutations in human germ cells
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Examples of germ cell mutagenicity:
▪2-Aminophenol
▪4-Aminophenol
▪Benzene
▪Aniline
▪1,2-Phenylenediamine
▪1,3-Phenylenediamine
▪Phenol
Labeling and classification of germ cell mutagenicity:
|
Classification
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Label
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Hazard statement code
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|
Hazard category
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Hazard classification
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Pictograms
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Signal word
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Hazard statement
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|
GHS
|
United Nations Model Regulations
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Germ cell mutagenicity
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1
(Subclasses 1A and 1B)
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|
None
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Danger
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May cause genetic defects
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H340
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2
|
|
None
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Warn
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Suspected possible genetic defect
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H341
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