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Skin Irritation Testing GB/T 21604-2008
GB / T 21604-2008 are provisions sets chemical skin irritation test methods, definitions, test results and criteria. The so-called skin irritation refers to reversible inflammation changes after chemical skin test.
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skin irritation test results
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Scores
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formation of erythema and eschar
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no erythema
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0
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very slight erythema
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1
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easy to determine erythema (clearly visible)
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2
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moderate to severe erythema
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3
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severe erythema (purple) to form eschar
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4
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formation of edema
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no edema
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0
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very slight edema (barely visible)
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1
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mild edema (skin bulge, clear outline)
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2
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severe edema (skin bulge about 1mm)
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3
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severe edema (skin bulge than 1mm, beyond the scope of exposed area)
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4
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For each test animal, we need sum erythema and edema scores in each observation time in order to obtain the total score of skin reactions, then calculate the average score of the total number in each observation time of test animals.
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skin irritation intensity grading
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skin irritation intensity
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average of the highest points
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no irritation
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0 ~ <0.5
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mild irritation
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0.5 to <2.0
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moderate irritation
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2.0 ~ 6.0
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strong irritation
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6.0~ 8.0
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